Session IIa: Metabolic Regulation and Tumour Suppression in Cell Death

Chair: Michelangelo Campanella

09:00-09:30

Christian Frezza - Cologne, Germany

Fumarate hydratase loss as a paradigm of oncometabolism

09:30-09:45

E. Candi -  Rome, Italy

Extracellular serine requirement identifies a therapeutic target for psoriasis

09:45-10:15

Dirk Brenner - Luxembourg

Regulatory T cell metabolism: cROSsroads between glutathione, serine and immune tolerance

10:15-10:30

M. Merkel - Marburg, Germany

Novel Ebselen-derivatives for pharmacological intervention of ferroptosis

10:30-11:00

Xin Lu – Oxford, UK

Infection and cancer, “kick and kill” strategy revisited

11:00-11:30

Coffee break

Session III: Tumour Suppression & Cell Death

Chair: TBA

11:30-12:00

Andreas Strasser – Melbourne, Australia

How does the tumour suppressor p53 instruct cell fate - survival or death

12:00-12:15

A. Janic - Barcelona, Spain

Dissecting the role of p53 target gene ZMAT3 in cancer development

12:15-12:30

G. Sullivan - Dublin, Ireland

Defining the pro-survival signalling of the bone marrow microenvironment of multiple myeloma

12:30-13:00

Ivano Amelio – Konstanz, Germany

Metabolism and Epigenetics as basis of p53-associated genomic integrity

13:00-15:00

Lunch & Poster Session I

Session IV: Integrity of Genome and Epigenome & Cell Death

Chair: Peter Vandenabeele

15:00-15:30

Thanos Halazonetis – Geneva, Switzerland

The fork protection complex and homologous recombination preserve the integrity of the replisome against conflicts with transcription

15:30-15:45

G. Liccardi, Cologne

Living in CIN: a cycle full inflammation and cell death

15:45-16:00

G. Kopeina, ECDO

Functional link between caspase-2 and p62 upon genotoxic stress is regulated by ubiquitination

16:00-16:15

W. Tonnus, Dresden

Gasdermin D-deficient mice are hypersensitive to acute kidney injury

16:15-16:45

Nicole Soranzo - Milan, Italy

Genomic approaches to study blood and immunity in human populations

16:45-17:15

Coffee break

Session V: Inflammation as cause & consequence of Cancer

Chair: Klaus-Michael Debatin

17:15-17:45

Erwin Wagner – Vienna, Austria

Inflammation and Neuro-Endocrine Control in Cancer Cachexia

17:45-18:00

J. Verhoeven, Leuven

Enhanced inflammatory signaling in autophagy deficient tumor endothelial cells promotes tumor immunosurveillance

18:00-18:15

I. Stolzer, Erlangen

Inter-organ crosstalk in the context of intestinal necroptosis and inflammation

18:15-18:45

Maria Sibilia - Vienna, Austria

Microenvironmental drivers of inflammation and tumorigenesis

18:45 - 21:00

Poster session II