Program and time schedule

Program and time schedule

14:00-14:10

Welcome by the Organizers

Pierluigi Nicotera & Gerry Melino

 

CDD Jurg Tschopp Prize to P.H. Krammer and K.M. Deabatin

14:10-14:50

Peter Krammer – Heidelberg, Germany

Apoptosis and tolerance through the new annexin checkpoint system

14:50-15:30

Klaus-Michael Debatin – Ulm, Germany

Sensitivity and Resistance in Cancer Therapy

 

Session Ia: Functional interactions in inflammation & Cell Death

Chair: Inna Lavrik

15:30-16:00

Manolis Pasparakis – Cologne, Germany

ZBP1 causes interferonopathy in ADAR1 mutant mice independently of necroptosis

16:00-16:15

S. van Wijk, Frankfurt

Dual roles of USP22 in IFN-mediated differentiation and cell fate signaling in disease

16:15-16:30

N. Peltzer, Cologne

Linear ubiquitination during obesity-induced inflammation

16:30-17:00

Henning Walczak - Cologne, Germany

Death receptor systems in cell death, inflammation and disease: a new TRAIL to overcoming cancer therapy resistance

17:00-17:20

Coffee break

 

 

 

17:20-17:50

Session Ib: Functional interactions in inflammation & Cell Death

Chair: Gerry Melino

 

Peter Vandenabeele - Ghent, Belgium

Is ferroptosis an immunogenic cell death (ICD) modality during prophylactic cancer vaccination?

17:50-18:05

A. Sampson, Melbourne

Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria

18:05- 18:35

Eicke Latz – Bonn, Germany

Identification of a novel inflammasome regulating cell death in keratinocytes

18:35- 19:20

ECDO Keynote Lecture

Tak Mak, Toronto, USA

Beyond Neurotransmission: The Role of Cholinergic Mediated Immune Signaling in Health and Disease

19:30-21:30

Welcome Reception & Poster Session I

 

 

Session IIa: Metabolic Regulation and Tumour Suppression in Cell Death

Chair: Michelangelo Campanella

09:00-09:30

Christian Frezza - Cologne, Germany

Fumarate hydratase loss as a paradigm of oncometabolism

09:30-09:45

E. Candi -  Rome, Italy

Extracellular serine requirement identifies a therapeutic target for psoriasis

09:45-10:15

Dirk Brenner - Luxembourg

Regulatory T cell metabolism: cROSsroads between glutathione, serine and immune tolerance

10:15-10:30

M. Merkel - Marburg, Germany

Novel Ebselen-derivatives for pharmacological intervention of ferroptosis

10:30-11:00

Xin Lu – Oxford, UK

Infection and cancer, “kick and kill” strategy revisited

11:00-11:30

Coffee break

 

Session III: Tumour Suppression & Cell Death

Chair: TBA

11:30-12:00

Andreas Strasser – Melbourne, Australia

How does the tumour suppressor p53 instruct cell fate - survival or death

12:00-12:15

A. Janic - Barcelona, Spain

Dissecting the role of p53 target gene ZMAT3 in cancer development

12:15-12:30

G. Sullivan - Dublin, Ireland

Defining the pro-survival signalling of the bone marrow microenvironment of multiple myeloma

   

12:30-13:00

Ivano Amelio – Konstanz, Germany

Metabolism and Epigenetics as basis of p53-associated genomic integrity

13:00-15:00

Lunch & Poster Session I

 

Session IV: Integrity of Genome and Epigenome & Cell Death

Chair: Peter Vandenabeele

15:00-15:30

Thanos Halazonetis – Geneva, Switzerland

The fork protection complex and homologous recombination preserve the integrity of the replisome against conflicts with transcription

15:30-15:45

G. Liccardi, Cologne

Living in CIN: a cycle full inflammation and cell death

15:45-16:00

G. Kopeina, ECDO

Functional link between caspase-2 and p62 upon genotoxic stress is regulated by ubiquitination

16:00-16:15

W. Tonnus, Dresden

Gasdermin D-deficient mice are hypersensitive to acute kidney injury

16:15-16:45

Nicole Soranzo - Milan, Italy

Genomic approaches to study blood and immunity in human populations

16:45-17:15

Coffee break

 

Session V: Inflammation as cause & consequence of Cancer

Chair: Klaus-Michael Debatin

17:15-17:45

Erwin Wagner – Vienna, Austria

Inflammation and Neuro-Endocrine Control in Cancer Cachexia

17:45-18:00

J. Verhoeven, Leuven

Enhanced inflammatory signaling in autophagy deficient tumor endothelial cells promotes tumor immunosurveillance

18:00-18:15

I. Stolzer, Erlangen

Inter-organ crosstalk in the context of intestinal necroptosis and inflammation

18:15-18:45

Maria Sibilia - Vienna, Austria

Microenvironmental drivers of inflammation and tumorigenesis

18:45 - 21:00

Poster session II

 

 

Session VI: Mechanisms of neuroinflammation

Chair: Daniele Bano

09:00-09:30

Michael Heneka – Bonn, Germany

TBA

09:30-09:45

L. van der Heide, Amsterdam

Cell death of dopamine neurons during development is driven by BH3-only factors

09:45-10:00

L. Wischhof, Bonn

The SWI/SNF subunit BCL7A primes OXPHOS to sustain the differentiation of neural progenitor cells

10:00-10:15

 

 

 

10:15-10:30

E. van San, Ghent

Targeting ferroptosis in multiple sclerosis

 

L Liu, Munich

“Nervous System-Derived MIF orchestrates cellular responses in Alzheimer’s Disease model

 

10:30-11:00

Bertrand Joseph – Stockholm, Sweden

The multitasking Microglia links Cancer and Neurodegeneration

11:00-11:30

Coffee break

 

Session VII: Cell Death in Infection

Chair: Henning Walczak

11:30-11:45

I. Schmitz, Bochum

c-FLIPR expression in Natural Killer cells impairs the early immune response to Influenza A virus infection

11:45-12:00

S. Bader, Melbourne

Dissecting the role of programmed cell death and inflammation in SARS-CoV-2 infection in vivo

12:00-12:15

D. Simpson, Melbourne

IFNγ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway licensed by nitric oxide

 

12:15-13:00

CDD Award to Ivan Dikic

Chair: Mauro Piacentini

Ivan Dikic – Frankfurt, Germany

Unconventional Serine Ubiquitination, Organelle Remodelling and Cell Death

13:00-14:00

Lunch

14:00-15:00

Poster Session II

 

Session VIII: Mechanisms of cell death in health & disease

Chair: Ivano Amelio

15:00-15:30

Dagmar Kulms - Dresden, Germany

Features of therapy resistance in malignant melanoma

15:30-15:45

L. Leanza, Padua

TG2 interaction with MITF is required for melanin synthesis and melanoma differentiation

15:45-16:00

M. Feoktistova, Aachen

RIPK1 and TRADD regulate TNF-induced signaling and ripoptosome formation

16:00-16:15

U. Ros, Cologne

Towards the regulation and execution of necroptosis

16:15-16:45

Giuseppe Testa – Milan, Italy

Brains in time: single cell resolved trajectories illuminate temporal phenotypes across neurodevelopmental disorders

16:45-17:15

Coffee break

 

Session VIIIb: Mechanisms of cell death in health & disease

Chair: Eleonora Candi

 

 

17:15-17:45

 

17:45-18:00

 

18:00-18:15

 

18:15-18:30

 

18:30-19:00

 

20:00


 

Andreas Linkermann - Dresden, Germany

17b-estradiol prevents kidney tubular ferroptosis to protect female tissue from ischemia-reperfusion injury

S. von Karstedt, Cologne

Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation

E. Lafont, Rennes

IRE1 RNase controls CD95-mediated cell death

B.L. Heckmann, Tampa

Beyond Autophagy - A novel mechanism of necroptotic regulation by the non-canonical autophagy protein Rubicon

P. Czabotar, Melbourne

Species Deceases: Understanding phylogenetic differences in the RIPK3-MLKL necroptotic switch

Conference Dinner

 

 

 

 

Session IX: Clinical advances and translational medicine

Chair: Patrizia Agostinis

09:00-09:30

R. Aqeilan, Jerusalem

Modeling and Characterizing WOREE Syndrome: from Basic Science to Translational Medicine

09:30-09:45

Y. Abdelwahab, Cologne

Targeting MLKL with small molecules to inhibit necroptosis

09:45-10:00

M. Vogler, Frankfurt

Mitochondrial apoptosis as facilitator of Natural Killer cell mediated immunotherapy

10:00-10:15

F. Wohlfromm, Magdeburg

Recombinant lactaptin analogon RL2 inhibits TRAIL-induced cell death in breast cancer cell lines by mitophagy

10:15-10:30

H. Bantel, Hannover

TNFR1 inhibition reduces lipogenesis and improves insulin resistance and fibrotic liver injury in NAFLD mice

10:30-10:45

B. Cappe, Gent

Extracellular vesicles from apoptosis, necroptosis and ferroptosis in L929 cells are all enriched in RNA binding proteinsCoffee break

10:45-11:15

Coffee Break

 

Session IXb: Clinical advances, neuroinflammation and translational medicine

Chair: Bertrand Joseph

11:15-11:45

A. Aschenbrenner, Bonn

Infectious disease, chronic inflammation and the potential impact on the brain

11:45-12:00

O. Gökce, Münich

Molecular characterization of the aging mouse white-matter reveals adaptive immune system as driver of oligodendrocyte loss

12:00-12:15

P. Androvic, Münich

Spatial Transcriptomics-correlated Electron Microscopy maps morphological and transcriptional responses to brain injury

12:15-12:30

K. Shkaryna, Munich

Optogenetic control of programmed cell death reveals the key role of bystander signaling in regulation of epithelial integrity and inflammatory response

12:30-13:00

J. Davila-Velderrain, Milan

TBA

 

 

13:00

Concluding Remarks by the Organisers, Poster Prize Award, Announcement of the next meeting

Pierluigi Nicotera & Gerry Melino

 

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Conference secretariat

Carlo Ganini MD, PhD

University of Rome Tor Vergata

Department of Experimental Medicine

Phone 333.6002286

e-mail: carlo.ganini@gmail.com

 

 

Ecke

CONTAG DRESDEN

Fetscherstraße 72
01307 Dresden

Tel: +49 (351) 652 86 37
Fax: +49 (351) 652 86 38
E-Mail: info@contag-dresden.de

ECDO secretariat

 

Vandevoorde Veronique
VIB-Ghent University Center for Inflammation Research
Technologiepark-Zwijnaarde 71
B-9052 Ghent (Zwijnaarde) Belgium
Tel: +32-(0)9-33-13682

e-mail: Veronique.Vandevoorde@irc.vib-UGent.be and ecdo@irc.ugent.be