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14:00-14:10
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Welcome by the Organizers
Pierluigi Nicotera & Gerry Melino
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CDD Jurg Tschopp Prize to P.H. Krammer and K.M. Deabatin
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14:10-14:50
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Peter Krammer – Heidelberg, Germany
Apoptosis and tolerance through the new annexin checkpoint system
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14:50-15:30
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Klaus-Michael Debatin – Ulm, Germany
Sensitivity and Resistance in Cancer Therapy
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Session Ia: Functional interactions in inflammation & Cell Death
Chair: Inna Lavrik
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15:30-16:00
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Manolis Pasparakis – Cologne, Germany
ZBP1 causes interferonopathy in ADAR1 mutant mice independently of necroptosis
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16:00-16:15
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S. van Wijk, Frankfurt
Dual roles of USP22 in IFN-mediated differentiation and cell fate signaling in disease
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16:15-16:30
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N. Peltzer, Cologne
Linear ubiquitination during obesity-induced inflammation
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16:30-17:00
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Henning Walczak - Cologne, Germany
Death receptor systems in cell death, inflammation and disease: a new TRAIL to overcoming cancer therapy resistance
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17:00-17:20
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Coffee break
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17:20-17:50
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Session Ib: Functional interactions in inflammation & Cell Death
Chair: Gerry Melino
Peter Vandenabeele - Ghent, Belgium
Is ferroptosis an immunogenic cell death (ICD) modality during prophylactic cancer vaccination?
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17:50-18:05
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A. Sampson, Melbourne
Endothelial Caspase-8 prevents fatal necroptotic hemorrhage caused by commensal bacteria
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18:05- 18:35
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Eicke Latz – Bonn, Germany
Identification of a novel inflammasome regulating cell death in keratinocytes
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18:35- 19:20
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ECDO Keynote Lecture
Tak Mak, Toronto, USA
Beyond Neurotransmission: The Role of Cholinergic Mediated Immune Signaling in Health and Disease
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19:30-21:30
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Welcome Reception & Poster Session I
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Session IIa: Metabolic Regulation and Tumour Suppression in Cell Death
Chair: Michelangelo Campanella
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09:00-09:30
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Christian Frezza - Cologne, Germany
Fumarate hydratase loss as a paradigm of oncometabolism
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09:30-09:45
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E. Candi, Rome
Extracellular serine requirement identifies a therapeutic target for psoriasis
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09:45-10:15
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Marcus Conrad - Munich, Germany
Ferroptosis as a pharmacologically amenable cell death modality in neurodegeneration
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10:15-10:30
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M. Merkel, Marburg
Novel Ebselen-derivatives for pharmacological intervention of ferroptosis
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10:30-11:00
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Xin Lu – Oxford, UK
Infection and cancer, “kick and kill” strategy revisited
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11:00-11:30
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Coffee break
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Session III: Tumour Suppression & Cell Death
Chair: TBA
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11:30-12:00
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Andreas Strasser – Melbourne, Australia
How does the tumour suppressor p53 instruct cell fate - survival or death
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12:00-12:15
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A. Janic, Barcelona
Dissecting the role of p53 target gene ZMAT3 in cancer development
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12:15-12:30
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G. Sullivan, Dublin
Defining the pro-survival signalling of the bone marrow microenvironment of multiple myeloma
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12:30-13:00
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Ivano Amelio – Konstanz, Germany
Metabolism and Epigenetics as basis of p53-associated genomic integrity
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13:00-15:00
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Lunch & Poster Session I
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Session IV: Integrity of Genome and Epigenome & Cell Death
Chair: Peter Vandenabeele
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15:00-15:30
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Thanos Halazonetis – Geneva, Switzerland
The fork protection complex and homologous recombination preserve the integrity of the replisome against conflicts with transcription
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15:30-15:45
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G. Liccardi, Cologne
Living in CIN: a cycle full inflammation and cell death
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15:45-16:00
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G. Kopeina, ECDO
Functional link between caspase-2 and p62 upon genotoxic stress is regulated by ubiquitination
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16:00-16:15
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W. Tonnus, Dresden
Gasdermin D-deficient mice are hypersensitive to acute kidney injury
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16:15-16:45
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Nicole Soranzo - Milan, Italy
Genomic approaches to study blood and immunity in human populations
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16:45-17:15
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Coffee break
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Session V: Inflammation as cause & consequence of Cancer
Chair: Klaus-Michael Debatin
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17:15-17:45
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Erwin Wagner – Vienna, Austria
Inflammation and Neuro-Endocrine Control in Cancer Cachexia
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17:45-18:00
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J. Verhoeven, Leuven
Enhanced inflammatory signaling in autophagy deficient tumor endothelial cells promotes tumor immunosurveillance
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18:00-18:15
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I. Stolzer, Erlangen
Inter-organ crosstalk in the context of intestinal necroptosis and inflammation
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18:15-18:45
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Maria Sibilia - Vienna, Austria
Microenvironmental drivers of inflammation and tumorigenesis
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18:45 - 21:00
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Poster session II
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Session VI: Mechanisms of neuroinflammation
Chair: Daniele Bano
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09:00-09:30
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Michael Heneka – Bonn, Germany
TBA
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09:30-09:45
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L. van der Heide, Amsterdam
Cell death of dopamine neurons during development is driven by BH3-only factors
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09:45-10:00
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L. Wischhof, Bonn
The SWI/SNF subunit BCL7A primes OXPHOS to sustain the differentiation of neural progenitor cells
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10:00-10:15
10:15-10:30
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E. van San, Ghent
Targeting ferroptosis in multiple sclerosis
L Liu, Munich
“Nervous System-Derived MIF orchestrates cellular responses in Alzheimer’s Disease model
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10:30-11:00
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Bertrand Joseph – Stockholm, Sweden
The multitasking Microglia links Cancer and Neurodegeneration
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11:00-11:30
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Coffee break
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Session VII: Cell Death in Infection
Chair: Henning Walczak
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11:30-11:45
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I. Schmitz, Bochum
c-FLIPR expression in Natural Killer cells impairs the early immune response to Influenza A virus infection
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11:45-12:00
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S. Bader, Melbourne
Dissecting the role of programmed cell death and inflammation in SARS-CoV-2 infection in vivo
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12:00-12:15
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D. Simpson, Melbourne
IFNγ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway licensed by nitric oxide
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12:15-13:00
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CDD Award to Ivan Dikic
Chair: Mauro Piacentini
Ivan Dikic – Frankfurt, Germany
Unconventional Serine Ubiquitination, Organelle Remodelling and Cell Death
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13:00-14:00
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Lunch
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14:00-15:00
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Poster Session II
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Session VIII: Mechanisms of cell death in health & disease
Chair: Ivano Amelio
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15:00-15:30
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Dagmar Kulms - Dresden, Germany
Features of therapy resistance in malignant melanoma
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15:30-15:45
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L. Leanza, Padua
TG2 interaction with MITF is required for melanin synthesis and melanoma differentiation
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15:45-16:00
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M. Feoktistova, Aachen
RIPK1 and TRADD regulate TNF-induced signaling and ripoptosome formation
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16:00-16:15
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U. Ros, Cologne
Towards the regulation and execution of necroptosis
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16:15-16:45
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Giuseppe Testa – Milan, Italy
Brains in time: single cell resolved trajectories illuminate temporal phenotypes across neurodevelopmental disorders
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16:45-17:15
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Coffee break
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Session VIIIb: Mechanisms of cell death in health & disease
Chair: Eleonora Candi |
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17:15-17:45
17:45-18:00
18:00-18:15
18:15-18:30
18:30-19:00
20:00
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Andreas Linkermann - Dresden, Germany
17b-estradiol prevents kidney tubular ferroptosis to protect female tissue from ischemia-reperfusion injury
S. von Karstedt, Cologne
Elevated FSP1 protects KRAS-mutated cells from ferroptosis during tumor initiation
E. Lafont, Rennes
IRE1 RNase controls CD95-mediated cell death
B.L. Heckmann, Tampa
Beyond Autophagy - A novel mechanism of necroptotic regulation by the non-canonical autophagy protein Rubicon
P. Czabotar, Melbourne
Species Deceases: Understanding phylogenetic differences in the RIPK3-MLKL necroptotic switch
Conference Dinner
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Session IX: Clinical advances and translational medicine
Chair: Patrizia Agostinis
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09:00-09:30
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R. Aqeilan, Jerusalem
Modeling and Characterizing WOREE Syndrome: from Basic Science to Translational Medicine
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09:30-09:45
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Y. Abdelwahab, Cologne
Targeting MLKL with small molecules to inhibit necroptosis
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09:45-10:00
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M. Vogler, Frankfurt
Mitochondrial apoptosis as facilitator of Natural Killer cell mediated immunotherapy
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10:00-10:15
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F. Wohlfromm, Magdeburg
Recombinant lactaptin analogon RL2 inhibits TRAIL-induced cell death in breast cancer cell lines by mitophagy
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10:15-10:30
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H. Bantel, Hannover
TNFR1 inhibition reduces lipogenesis and improves insulin resistance and fibrotic liver injury in NAFLD mice
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10:30-10:45
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B. Cappe, Gent
Extracellular vesicles from apoptosis, necroptosis and ferroptosis in L929 cells are all enriched in RNA binding proteinsCoffee break
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10:45-11:15
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Coffee Break
Session IXb: Clinical advances, neuroinflammation and translational medicine
Chair: Bertrand Joseph
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11:15-11:45
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A. Aschenbrenner, Bonn
Infectious disease, chronic inflammation and the potential impact on the brain
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11:45-12:00
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O. Gökce, Münich
Molecular characterization of the aging mouse white-matter reveals adaptive immune system as driver of oligodendrocyte loss
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12:00-12:15
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P. Androvic, Münich
Spatial Transcriptomics-correlated Electron Microscopy maps morphological and transcriptional responses to brain injury
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12:15-12:30
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K. Shkaryna, Munich
Optogenetic control of programmed cell death reveals the key role of bystander signaling in regulation of epithelial integrity and inflammatory response
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12:30-13:00
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J. Davila-Velderrain, Milan
TBA
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13:00
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Concluding Remarks by the Organisers, Poster Prize Award, Announcement of the next meeting
Pierluigi Nicotera & Gerry Melino
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Carlo Ganini MD, PhD 
