Program and time schedule

Program and time schedule

Wednesday September 27, 2017

12:30 – 19:00  -  Registration

13.00 – 15:30

Session 1a: Cell autonomous pathways modulating cell death -
CHAIR: Boris Zhivotovsky

13:00 - 13:15

Brief historical introduction by Boris Zhivotovsky


Ana MARTIN VILLALBA (Heidelberg, Germany)
Unravelling how CD95 decides between life and death


Inna Lavrik (Magdeburg, Germany)
Quantitative single cell analysis uncovers the life/death decision in the death receptor network


Dagmar Kulms (Dresden, Germany)
Cancer cells employ nuclear caspase-8 to overcome the p53-dependent G2/M checkpoint


Cristina Muñoz-Pinedo (Barcelona, Spain)
Starvation induces the Unfolded Protein Response and cell death by necrosis or death receptor-mediated apoptosis


Ken CADWELL (New york, USA)
Autophagy and the intestinal barrier
Jessie GUO (New Jersey, USA)
Inhibiting autophagy as a cancer therapy for Kras-driven lung cancer

Sponsor presentations

Caroline Boeckx (Roche)
Evaluation of the tumor microenvironment
Sofia Vikstrom (Agilent)
Measuring metabolic phenotypes using the Agilent Seahorse XF Technology

15.40 – 16:15

Coffee break

16:15 – 18:30

Session 1b: Cell autonomous pathways modulating cell death -
CHAIR: Zahra Zakeri & Simone Fulda

Fabio MARTINON (Geneva, Switzerland)
Characterisation of a stress-response protease that contributes to proteostasis
Marcus CONRAD (Neuherberg, Germany)
Ferroptosis: mechanisms, in vivo relevance and therapeutic potential
Katherine Davies (Parkville, Australia)
Examining the role of the brace region in Mixed Lineage Kinase domain-Like protein (MLKL) oligomerisation and activation
Markus Rehm (Stuttgart, Germany)
Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711
Yves Dondelinger (Ghent, Belgium)
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
Gianmaria Liccardi (London, UK)
The Mitotic Ripoptosome: an apoptotic and necroptotic cell death checkpoint during prolonged mitosis

Sponsor presentations

Toon De Roeve (Essen Bioscience)
IncuCyte® S3 - Live-Cell Imaging and Analysis around-the-clock
Martine Vanhoucke (BCCM/LMBP)
The Belgian BCCM/LMBP Plasmid Collection: a service by scientists for scientists
18:30 – 18:50
Official opening of the 25th Euroconference on Cell Death Research
Word by the rector of KU Leuven
18:50 - 20:00
ECDO Honorary and CDD Jurg Tschopp Prize - Lecture: Doug GREEN (Memphis, USA), introduced by the President of ECDO Seamus Martin
Targeting LAP: LC3-associated phagocytosis of dying cells in autoinflammation and anti-cancer immunityand back!

20:00 – 22:00

Opening reception (with drinks and bites and music)


Thursday September 28, 2017

08:45 – 11:30

Session 2a: Cell death & phagocytosis -
Chair: Hans-Uwe Simon

08:45 - 09:00

Brief historical introduction by Hans-Uwe Simon

09:00 -09:30
Will WOOD (Bristol, UK)
Detecting Death and Damage; Understanding macrophage migration in Drosophila
09:30 -10:00
Martin HERRMANN (Erlangen-Nuremberg, Germany)
NET formation and aggregation contribute to initiation and resolution of neutrophil-driven inflammation
10:00 -10:15
Saskia Cillissen (Amsterdam, the Netherlands)
Villous atrophy in RCDII is caused by granzyme-B mediated apoptosis of enterocytes by aberrant IEL via CD103-E-cadherin interaction
10:15 -10:30
Alessandro Annibaldi (London, UK)
MK2 phosphorylates RIPK1 to prevent TNF induced cell death

10:30 - 11:00

Coffee break

11:00  – 12:35

Session 2b: Cell death & phagocytosis -
Chair: Marie-Lise Gougeon

Venizelos PAPAYANNOPOULOS (London, UK)
How neutrophils regulate inflammation
Claudio HETZ (Santiago, Chile)
TMBIM protein family: ancestral regulators of cell death
Ramona Reinhart (Bern, Switzerland)
Efficient apoptosis induction in mouse basophils and mast cells by BH3 mimetic compounds
12:15 – 12:35
Flash talks -Session 1: P-1, 11, 12, 20, 23, 36, 62, 74, 78

12:35 – 14:15

Lunch on site

14:15 – 16:00

Session 3a: Cell death and Inflammation -
Chair: Peter Vandenabeele

14:15 – 14:30

Brief historical introduction by Peter Vandenabeele

Mohamed LAMKANFI (Gent, Belgium)
Anthrax lethal toxin licenses RIPK1 kinase activity-dependent NLRP3 inflammasome activation and macrophage cytotoxicity
Monica Yabal (Munich, Germany)
XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1b Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation
Inge Verbrugge (Amsterdam, the Netherlands)
Mechanisms underlying combined local and systemic responses to radio-immunotherapy
15:30 -16:00
Manolis PASPARAKIS (Cologne, Germany)
RIPK1 in cell death and inflammation

16:00 - 16:30

Coffee break

16:30 – 18:45

Session 3b: Cell death and Inflammation -
chair: Henning Walczak

Marisol SOENGAS (Madrid, Spain)
MetAlert mice: a platform for whole-body imaging and pharmacological targeting of metastatic niches
Tom Vanden Berghe (Ghent, Belgium)
Natural ferroptosis-inducing compounds, key to eradicate highly resistant tumors?
Fabian Schuler (Innsbruck, Austria)
Checkpoint kinase 1 (CHK1) controls normal B cell development, lymphomagenesis and cancer cell survival
Benedicte PY (Lyon, France)
Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
18:00 - 18:45
1st Keynote Lecture: Kodi RAVICHANDRAN (Virginia, USA & Gent, Belgium)
Rethinking the cell clearance process and its implications
18:45 – 19:00
General Assembly

19:00- 22:00

Poster session 1 (even poster numbers)+ refreshments


Friday September 29, 2017

08:45 – 10:30

Session 4a: Cell death, tissue repair and microenvironment -
chair: Mauro Piacentini

08:45 - 09:00

Brief historical introduction by Mauro Piacentini

09:00 -09:30
Gabriele BERGERS (Leuven, Belgium)
Vascular and Immune conditioning to eradicate tumors
09:30 -10:00
Hector PEINADO (Madrid, Spain)
Influence of tumor-secreted exosomes in pre-metastatic niche formation
10:00 -10:15
Manuel Ehling (Leuven, Belgium)
PP2A/B55α regulates endothelial cell protection against apoptosis during vascular remodeling and pathological angiogenesis
10:15 -10:30
Aida Freire-Valls (Heidelberg, Germany)
Caspase-8 regulates postnatal angiogenesis via MAPK P38 and VE-cadherin

10:30 - 11:00

Coffee break

11:00 – 13:00

Session 4b: Cell death, tissue repair and microenvironment -
chairs: Patrizia Agostinis & Boris Turk

Massimiliano MAZZONE (Leuven, Belgium)
The killing kiss of phosphatase blockade in cancer 
Jannie BORST (Amsterdam, The Netherlands)
How to exploit the vaccine potential of radiotherapy
Anje Cauwels (Ghent, Belgium)
Targeting type I interferon activity to the tumor microenvironment or to dendritic cells synergizes with immunogenic chemotherapy to safely eradicate tumors
Marco Schaaf (Leuven, Belgium)
The role of endothelial cell-associated autophagy in melanoma growth
Olivier De Wever (Ghent, Belgium)
Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF-1R activation
12:45– 13:05
Flash talks -Session 2: P-3, 5, 9, 13, 45, 57, 63, 65, 73

13:05 – 15:45

Lunch on site + Poster session 2 (uneven poster numbers)

15:45 – 17:30

Session 5: Harnessing cell death and immunity crosstalk in translational medicine -
chairs: Klaus-Michael Debatin & Peter Krammer

15:45 - 16:00

Brief historical introduction by Klaus-Michael Debatin

Michael HENEKA (Bonn, Germany)
Microglial demise and the progression of Alzheimer’s disease
Andreas Linkermann (Dresden, Germany)
Necroptosis controls NET generation and mediates complement activation, endothelial damage and autoimmune vasculitis
Julia Zinngrebe (Ulm, Germany)
The linear ubiquitin chain assembly complex is a crucial regulator of toll-like receptor 3 signaling
Silvia Chiara FORMENTI (NY, USA)
Ionizing Radiation-Induced Immunogenic cell death
17:30 - 18:15
2nd Keynote Lecture: Alberto MANTOVANI (Rozzano, Italy)
The yin yang of tumor-associated macrophages in cancer progression
Poster and flash talk awards & Wrap-up

19:15– 20:30

Reception at the City Hall of Leuven (offered by the town of Leuven)


Conference dinner at Groot Begijnhof (for registered delegates)