Program and time schedule

Program and time schedule

Wednesday September 27, 2017

12:30 – 19:00  -  Registration

13.00 – 15:30

Session 1a: Cell autonomous pathways modulating cell death -
CHAIR: Boris Zhivotovsky

13:00 - 13:15

Brief historical introduction by Boris Zhivotovsky

 

13:15-13:45
Ana MARTIN VILLALBA (Heidelberg, Germany)
Unravelling how CD95 decides between life and death

 

13:45-14:00
Inna Lavrik (Magdeburg, Germany)
Quantitative single cell analysis uncovers the life/death decision in the death receptor network

 

14:00-14:15
Dagmar Kulms (Dresden, Germany)
Cancer cells employ nuclear caspase-8 to overcome the p53-dependent G2/M checkpoint

 

14:15-14:30
Cristina Muñoz-Pinedo (Barcelona, Spain)
Starvation induces the Unfolded Protein Response and cell death by necrosis or death receptor-mediated apoptosis

 

14:30-15:00
Ken CADWELL (New york, USA)
Autophagy and the intestinal barrier
 
15:00-15:30
Jessie GUO (New Jersey, USA)
Inhibiting autophagy as a cancer therapy for Kras-driven lung cancer
  15:30-15:40

Sponsor presentations

Caroline Boeckx (Roche)
Evaluation of the tumor microenvironment
Sofia Vikstrom (Agilent)
Measuring metabolic phenotypes using the Agilent Seahorse XF Technology

15.40 – 16:15

Coffee break

16:15 – 18:30

Session 1b: Cell autonomous pathways modulating cell death -
CHAIR: Zahra Zakeri & Simone Fulda

 
16:15-16:45
Fabio MARTINON (Geneva, Switzerland)
Characterisation of a stress-response protease that contributes to proteostasis
 
16:45-17:15
Marcus CONRAD (Neuherberg, Germany)
Ferroptosis: mechanisms, in vivo relevance and therapeutic potential
 
17:15-17:30
Katherine Davies (Parkville, Australia)
Examining the role of the brace region in Mixed Lineage Kinase domain-Like protein (MLKL) oligomerisation and activation
 
17:30-17:45
Markus Rehm (Stuttgart, Germany)
Simulating and predicting cellular and in vivo responses of colon cancer to combined treatment with chemotherapy and IAP antagonist Birinapant/TL32711
 
17:45-18:00
Yves Dondelinger (Ghent, Belgium)
MK2 phosphorylation of RIPK1 regulates TNF-mediated cell death
 
18:00-18:15
Gianmaria Liccardi (London, UK)
The Mitotic Ripoptosome: an apoptotic and necroptotic cell death checkpoint during prolonged mitosis
 
18:15-18:30

Sponsor presentations

Toon De Roeve (Essen Bioscience)
IncuCyte® S3 - Live-Cell Imaging and Analysis around-the-clock
Martine Vanhoucke (BCCM/LMBP)
The Belgian BCCM/LMBP Plasmid Collection: a service by scientists for scientists
18:30 – 18:50
Official opening of the 25th Euroconference on Cell Death Research
Word by the rector of KU Leuven
18:50 - 20:00
ECDO Honorary and CDD Jurg Tschopp Prize - Lecture: Doug GREEN (Memphis, USA), introduced by the President of ECDO Seamus Martin
Targeting LAP: LC3-associated phagocytosis of dying cells in autoinflammation and anti-cancer immunityand back!

20:00 – 22:00

Opening reception (with drinks and bites and music)

 

Thursday September 28, 2017

08:45 – 11:30

Session 2a: Cell death & phagocytosis -
Chair: Hans-Uwe Simon

08:45 - 09:00

Brief historical introduction by Hans-Uwe Simon

 
09:00 -09:30
Will WOOD (Bristol, UK)
Detecting Death and Damage; Understanding macrophage migration in Drosophila
 
09:30 -10:00
Martin HERRMANN (Erlangen-Nuremberg, Germany)
NET formation and aggregation contribute to initiation and resolution of neutrophil-driven inflammation
 
10:00 -10:15
Saskia Cillissen (Amsterdam, the Netherlands)
Villous atrophy in RCDII is caused by granzyme-B mediated apoptosis of enterocytes by aberrant IEL via CD103-E-cadherin interaction
 
10:15 -10:30
Alessandro Annibaldi (London, UK)
MK2 phosphorylates RIPK1 to prevent TNF induced cell death

10:30 - 11:00

Coffee break

11:00  – 12:35

Session 2b: Cell death & phagocytosis -
Chair: Marie-Lise Gougeon

 
11:00-11:30
Venizelos PAPAYANNOPOULOS (London, UK)
How neutrophils regulate inflammation
 
11:30-12:00
Claudio HETZ (Santiago, Chile)
TMBIM protein family: ancestral regulators of cell death
 
12:00-12:15
Ramona Reinhart (Bern, Switzerland)
Efficient apoptosis induction in mouse basophils and mast cells by BH3 mimetic compounds
12:15 – 12:35
Flash talks -Session 1: P-12, 20, 36, 62, 74, 78

12:35 – 14:15

Lunch on site

14:15 – 16:00

Session 3a: Cell death and Inflammation -
Chair: Peter Vandenabeele

14:15 – 14:30

Brief historical introduction by Peter Vandenabeele

 
14:30-15:00
Mohamed LAMKANFI (Gent, Belgium)
Anthrax lethal toxin licenses RIPK1 kinase activity-dependent NLRP3 inflammasome activation and macrophage cytotoxicity
 
15:00-15:15
Monica Yabal (Munich, Germany)
XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1b Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation
 
15:15-15:30
Inge Verbrugge (Amsterdam, the Netherlands)
Mechanisms underlying combined local and systemic responses to radio-immunotherapy
 
15:30 -16:00
Manolis PASPARAKIS (Cologne, Germany)
RIPK1 in cell death and inflammation

16:00 - 16:30

Coffee break

16:30 – 18:45

Session 3b: Cell death and Inflammation -
chair: Henning Walczak

 
16:30-17:00
Marisol SOENGAS (Madrid, Spain)
MetAlert mice: a platform for whole-body imaging and pharmacological targeting of metastatic niches
 
17:00-17:15
Tom Vanden Berghe (Ghent, Belgium)
Natural ferroptosis-inducing compounds, key to eradicate highly resistant tumors?
 
17:15-17:30
Fabian Schuler (Innsbruck, Austria)
Checkpoint kinase 1 (CHK1) controls normal B cell development, lymphomagenesis and cancer cell survival
 
17:30-18:00
Benedicte PY (Lyon, France)
Deubiquitination of NLRP3 by BRCC3 critically regulates inflammasome activity
18:00 - 18:45
1st Keynote Lecture: Kodi RAVICHANDRAN (Virginia, USA & Gent, Belgium)
Rethinking the cell clearance process and its implications
18:45 – 19:00
General Assembly

19:00- 22:00

Poster session 1 (even poster numbers)+ refreshments

 

Friday September 29, 2017

08:45 – 10:30

Session 4a: Cell death, tissue repair and microenvironment -
chair: Mauro Piacentini

08:45 - 09:00

Brief historical introduction by Mauro Piacentini

 
09:00 -09:30
Gabriele BERGERS (Leuven, Belgium)
Vascular and Immune conditioning to eradicate tumors
 
 
09:30 -10:00
Hector PEINADO (Madrid, Spain)
Influence of tumor-secreted exosomes in pre-metastatic niche formation
 
 
10:00 -10:15
Manuel Ehling (Leuven, Belgium)
PP2A/B55α regulates endothelial cell protection against apoptosis during vascular remodeling and pathological angiogenesis
 
 
10:15 -10:30
Aida Freire-Valls (Heidelberg, Germany)
Caspase-8 regulates postnatal angiogenesis via MAPK P38 and VE-cadherin
 

10:30 - 11:00

Coffee break

11:00 – 13:00

Session 4b: Cell death, tissue repair and microenvironment -
chairs: Patrizia Agostinis & Boris Turk

 
11:00-11:30
Massimiliano MAZZONE (Leuven, Belgium)
The killing kiss of phosphatase blockade in cancer 
 
 
11:30-12:00
Jannie BORST (Amsterdam, The Netherlands)
How to exploit the vaccine potential of radiotherapy
 
 
12:00-12:15
Anje Cauwels (Ghent, Belgium)
Targeting type I interferon activity to the tumor microenvironment or to dendritic cells synergizes with immunogenic chemotherapy to safely eradicate tumors
 
 
12:15-12:30
Marco Schaaf (Leuven, Belgium)
The role of endothelial cell-associated autophagy in melanoma growth
 
  12:30-12:45
Olivier De Wever (Ghent, Belgium)
Radiotherapy-activated cancer-associated fibroblasts promote tumor progression through paracrine IGF-1R activation
 
12:45– 13:05
Flash talks -Session 2: P-1, 3, 5, 9, 11, 13, 23, 45, 57, 63, 65, 73

13:05 – 15:45

Lunch on site + Poster session 2 (uneven poster numbers)

15:45 – 17:30

Session 5: Harnessing cell death and immunity crosstalk in translational medicine -
chairs: Klaus-Michael Debatin & Peter Krammer

15:45 - 16:00

Brief historical introduction by Klaus-Michael Debatin

 
16:00-16:30
Michael HENEKA (Bonn, Germany)
Microglial demise and the progression of Alzheimer’s disease
 
 
16:30-16:45
Andreas Linkermann (Dresden, Germany)
Necroptosis controls NET generation and mediates complement activation, endothelial damage and autoimmune vasculitis
 
 
16:45-17:00
Julia Zinngrebe (Ulm, Germany)
The linear ubiquitin chain assembly complex is a crucial regulator of toll-like receptor 3 signaling
 
 
17:00-17:30
Silvia Chiara FORMENTI (NY, USA)
Ionizing Radiation-Induced Immunogenic cell death
 
17:30 - 18:15
2nd Keynote Lecture: Alberto MANTOVANI (Rozzano, Italy)
The yin yang of tumor-associated macrophages in cancer progression
 
18:15-18:45
Poster and flash talk awards & Wrap-up
 

19:15– 20:30

Reception at the City Hall of Leuven (offered by the town of Leuven)

20:45

Conference dinner at Groot Begijnhof (for registered delegates)