Program and time schedule

Program and time schedule

Wednesday September 28, 2016

11:00 – 19:00  -  Registration

13:00 - 13:15

Welcome address - Presentation of the COST PROTEOSTASIS network

13.15 – 15:00

Session 1: Non-apoptotic death and autophagy

chair: Christian Widmann (Lausanne, Switzerland)
 
13:15-13:45
David KOMANDER (Cambridge, UK)
Regulating ubiquitin signals by deubiquitinases
 
13:45-14:00
José Pedro Friedmann Angeli (Neuherberg, Germany)
Acsl4 determines ferroptosis sensitivity by decreasing the content of arachidonoyl and adrenoyl containing phosphatidyl-ethanolamines
 
14:00-14:15
Kristel Martínez-Lagunas (Bonn, Germany)
In vivo detection of programmed cell death during mouse heart development
 
14:15-14:30
Ed Mocarski (Atlanta, USA)
Caspase-8 Executes Endotoxic Shock
 
14:30-15:00
Fumiyo IKEDA (Vienna, Austria)
Ubiquitin enzymes in the regulation of non-selective autophagy
 

15:00 – 15:20

Flash talks -Session 1

chair: Seamus Martin (Dublin, Ireland)
Benjamin Cappe, Lisandra Castro, Danielle M. Clancy, Marco Cordani, Eugenia Delgado, Caitriona Holohan, Manhyung Jeong, Gianmaria Liccardi,Joanna Majkut, Jara Majuelos-Melguizo

15.20 – 16:00

Coffee break

16:00 – 18:30

Session 1b: Non-apoptotic death and autophagy

chair: Xuejun Jiang (New York, USA)
 
16:00-16:30
Eric BAEHRECKE  (Worcester, USA)
Autophagy, Cell Health and Cell Death
 
16:30-17:00
Patrice CODOGNO (Paris, France)
Lysosome at the crossroads of iron and targeting of breast cancer stem cells
 
17:00-17:15
Triona Ni Chonghaile (Dublin, Ireland)
A cancer selective small molecule that kills independent of mitochondrial apoptosis was identified from a high-throughput screen
 
17:15-17:45
Oriol CASANOVAS (Madrid, Spain)
Death and Survival after Antiangiogenic Therapies: the Metabolic Symbiosis Escape
 
17:45-18:15
Kevin RYAN (Glasgow, Scotland)
Mechanisms of macroautophagy in the cell death and cancer
  18:15-18:45
ECDO general Assembly

19:00 – 21:00

Poster session 1

(refreshments and bites on site)

 

Thursday September 29, 2016

09:00  – 12:45

Session 2: Bcl-2 family, metabolism and cancer

Chair: Solange Desagher (Montpellier, France)
 
09:30 -10:00    
Tony LETAI  (Boston, USA)
Clinical success in targeting apoptosis in cancer cell mitochondria
 
10:00 -10:30
Jean-Claude MARTINOU (Geneva, Switzerland)
The mitochondrial pyruvate carrier: regulation of its activity in cancer cells
 
10:30 -10:45
Jerry Chipuk (New York, USA)
BAX-dependent mitochondrial outer membrane permeabilization: exquisitely regulated to the point of death.
 
10:45 -11:00
Mar Orzáez (Valencia, Spain)
The Bax transmembrane domain interacts with Bcl-2 proteins in non-apoptotic cells

11:00 - 11:30

Coffee break

11:30  – 12:45

Session 2b: Bcl-2 family, metabolism and cancer

Chair: Philippe Juin (Nantes, France)
 
11:30-12:00
Jean-Ehrland  RICCI (Nice, France)
Metabolic control of cell death
 
12:00-12:15
Patricia Gomez-Bougie (Nantes, France)
Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couples ER stress to mitochondrial apoptosis
 
12:15-12:30
Sandrine Marchetti (Nice, France)
The oncogenic tyrosine kinase Lyn modulates Bim pro-apoptotic function
 
12:30-12:45
Prafull Kumar Singh (Freiburg, Germany)
Dynein light chain 1 mediated oligomerisation on mitochondria regulates the pro-apoptotic activity of the BH3-only protein Bim

12:45 – 14:00

Lunch on site

14:00 – 15:30

Session 3: Stress and cell death

Chair: Beatrice Bailly-Maitre (Nice, France)
 
14:00-14:30
Avi ASHKENAZI (San Francisco, USA)
Control of Apoptosis by the Unfolded Protein Response
 
14:30-15:00
Eric CHEVET (Rennes, France)
Antagonistic IRE1 RNase signals dictate glioblastoma tumor development
 
15:00-15:15
Susan Logue (Galway, Ireland)
Inhibition of IRE1a RNase activity modulates the secretome of Triple Negative Breast Cancer cells and enhances the effectiveness of chemotherapy
  15:15 -15:30
Beatriz Martín-Antonio (Barcelona, Spain)

Natural killer cells transfer antimicrobial and antitumoral Histone H2AZ to kill multiple myeloma cells contributing to transmissible cytotoxicity

15:30 – 15:50

Flash talks - Session 2

Chair: Simone Fulda (Frankfurt, Germany)
 
Seung-Won Choi (poster Noh), Adrien Nougarede, Michaela Ohmer, Jinho Seo, Raquel Salvador-Gallego, Doaa Tawfik, Selma Tuzlak, Juan Garcia Valero, Sarka Vosahlikova, Tianqi Xu

15:50 - 16:20

Coffee break

16:20 – 18:15

Session 3b: Stress and cell death

Chair: Francois Vallette (Nantes, France)

 
16:20-16:50
Boris TURK (Ljubljana, Slovenia)
Cysteine cathepsins: cell killing or tumor promoting in cancer?
 
16:50-17:20
Guido KROEMER (Paris, France)
Immunogenic cell stress and death in anticancer immunosurveillance
 
17:20-17:35
Raffaella Iurlaro (Barcelona, Spain)
Glucose deprivation induces ATF4-mediated apoptosis through TRAIL receptors DR4/TRAIL-R1 and DR5/TRAIL-R2
 
17:35-18:15
CDD Jurg Tshopp award presentation: Peter Vandenabeele (Ghent, Belgium)
Regulation of the core necroptosis pathway by nuclear events

18:15- 20:15

Poster session 2

(+ refreshments)

 

 

Friday September 30, 2016

09:00 – 12:45

Session 4: Inflammation and cell death

Chairs: Gerry Melino (Rome/Leicester, UK) - Thomas Brunner (Konstanz, Germany)
 
09:30-10:00
John BERTIN (Pennsylvania, USA)
RIPK1 therapeutics—From concept to patients with immune-mediated inflammatory diseases
 
10:00-10:30
Domagoj VUCIC (San Francisco, USA)
Regulation of inflammation and cell death by RIP kinases
 
10:30-10:45
Ulrich Maurer (Freiburg, Germany)
SPATA2 promotes CYLD activity and regulates TNF-induced NF-kB signaling and cell death

10:45 - 11:15

Coffee break

 
11:15-11:45
Henning  WALCZAK (London, UK)
Cell death in cancer, inflammation and immunity
 
11:45-12:15
Seamus MARTIN (Dublin, Ireland)
TRAIL-induced Inflammatory signaling: a DISC with a Twist
 
12:15-12:30
Lynn Wong (Zurich, Switzerland)
RIPK3 promotes vascular permeability via VEGF/p38 axis to allow tumor cell extravasation independent of its kinase activity

12:30 – 14:00

Lunch on site

14:00 – 15:30

Session 5: Death Receptors and caspase activating complexes

Chair : Núria Sánchez-Coll, Barcelona, Spain
 
14:00-14:30
Marion MACFARLANE (Leicester, UK)
A Unified Model for c-FLIP regulation of Caspase-8 and control of life/death decisions
 
14:30-15:00
Andreas VILLUNGER (Innsbruck, Austria)
Controlling cell death in and out of mitosis
 
15:00-15:15
Eli Arama (Rehovot, Israel)
Caretakers of tissue integrity: A non-apoptotic role of caspases in preventing unwanted cell migration and invasion
 
15:15-15:30
Dagmar Kulms (Dresden, Germany)
Caspase-8 promotes uncontrolled progression of cancer cells

15:30 - 16:00

Coffee break

16:00 – 18:00

Session 6: Death modulators in the clinic

Chair: Joan Gil, Barcelona, Spain
 
16:00-16:15
Eric Eldering (Amsterdam, Netherlands)
BH3 mimetics as combination drugs and as profiling tools in CLL
 
16:15-16:30
Joan Montero (Boston, USA)
Using Dynamic BH3 Profiling to employ BH3 mimetics for improving cancer treatment
 
16:30-16:45
Markus Rehm (Stuttgart, Germany)
A stepwise integrated approach to personalized risk predictions in stage III colorectal cancer building on tumor apoptosis competency
 
16:45-17:00
Ana Janic (Melbourne, Australia)
shRNA screens indicate that DNA repair is the process critical for p53-mediated tumour suppression
 
17:00-18:00
ECDO Honorary Lecture: Andreas STRASSER (Melbourne, Australia)
Which pro-survival BCL-2 family member should be targeted for the treatment of which cancer?
 
18:00-18:10
Poster and flash talk awards
 
18:10-18:20
Wrap-up

20:30

Conference dinner

 

                      

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