Program and time schedule

Program and time schedule

Wednesday September 28, 2016

11:00 – 19:00  -  Registration

13:00 - 13:15

Welcome address - Presentation of the COST PROTEOSTASIS network

13.15 – 15:00

Session 1: Non-apoptotic death and autophagy

chair: Christian Widmann (Lausanne, Switzerland)
David KOMANDER (Cambridge, UK)
Regulating ubiquitin signals by deubiquitinases
José Pedro Friedmann Angeli (Neuherberg, Germany)
Acsl4 determines ferroptosis sensitivity by decreasing the content of arachidonoyl and adrenoyl containing phosphatidyl-ethanolamines
Kristel Martínez-Lagunas (Bonn, Germany)
In vivo detection of programmed cell death during mouse heart development
Ed Mocarski (Atlanta, USA)
Caspase-8 Executes Endotoxic Shock
Fumiyo IKEDA (Vienna, Austria)
Ubiquitin enzymes in the regulation of non-selective autophagy

15:00 – 15:20

Flash talks -Session 1

chair: Seamus Martin (Dublin, Ireland)
Benjamin Cappe, Lisandra Castro, Danielle M. Clancy, Marco Cordani, Eugenia Delgado, Caitriona Holohan, Manhyung Jeong, Gianmaria Liccardi,Joanna Majkut, Jara Majuelos-Melguizo

15.20 – 16:00

Coffee break

16:00 – 18:30

Session 1b: Non-apoptotic death and autophagy

chair: Xuejun Jiang (New York, USA)
Eric BAEHRECKE  (Worcester, USA)
Autophagy, Cell Health and Cell Death
Patrice CODOGNO (Paris, France)
Lysosome at the crossroads of iron and targeting of breast cancer stem cells
Triona Ni Chonghaile (Dublin, Ireland)
A cancer selective small molecule that kills independent of mitochondrial apoptosis was identified from a high-throughput screen
Oriol CASANOVAS (Madrid, Spain)
Death and Survival after Antiangiogenic Therapies: the Metabolic Symbiosis Escape
Kevin RYAN (Glasgow, Scotland)
Mechanisms of macroautophagy in the cell death and cancer
ECDO general Assembly

19:00 – 21:00

Poster session 1

(refreshments and bites on site)


Thursday September 29, 2016

09:00  – 12:45

Session 2: Bcl-2 family, metabolism and cancer

Chair: Solange Desagher (Montpellier, France)
09:30 -10:00    
Tony LETAI  (Boston, USA)
Clinical success in targeting apoptosis in cancer cell mitochondria
10:00 -10:30
Jean-Claude MARTINOU (Geneva, Switzerland)
The mitochondrial pyruvate carrier: regulation of its activity in cancer cells
10:30 -10:45
Jerry Chipuk (New York, USA)
BAX-dependent mitochondrial outer membrane permeabilization: exquisitely regulated to the point of death.
10:45 -11:00
Mar Orzáez (Valencia, Spain)
The Bax transmembrane domain interacts with Bcl-2 proteins in non-apoptotic cells

11:00 - 11:30

Coffee break

11:30  – 12:45

Session 2b: Bcl-2 family, metabolism and cancer

Chair: Philippe Juin (Nantes, France)
Jean-Ehrland  RICCI (Nice, France)
Metabolic control of cell death
Patricia Gomez-Bougie (Nantes, France)
Repression of Mcl-1 and disruption of the Mcl-1/Bak interaction in myeloma cells couples ER stress to mitochondrial apoptosis
Sandrine Marchetti (Nice, France)
The oncogenic tyrosine kinase Lyn modulates Bim pro-apoptotic function
Prafull Kumar Singh (Freiburg, Germany)
Dynein light chain 1 mediated oligomerisation on mitochondria regulates the pro-apoptotic activity of the BH3-only protein Bim

12:45 – 14:00

Lunch on site

14:00 – 15:30

Session 3: Stress and cell death

Chair: Beatrice Bailly-Maitre (Nice, France)
Avi ASHKENAZI (San Francisco, USA)
Control of Apoptosis by the Unfolded Protein Response
Eric CHEVET (Rennes, France)
Antagonistic IRE1 RNase signals dictate glioblastoma tumor development
Susan Logue (Galway, Ireland)
Inhibition of IRE1a RNase activity modulates the secretome of Triple Negative Breast Cancer cells and enhances the effectiveness of chemotherapy
  15:15 -15:30
Beatriz Martín-Antonio (Barcelona, Spain)

Natural killer cells transfer antimicrobial and antitumoral Histone H2AZ to kill multiple myeloma cells contributing to transmissible cytotoxicity

15:30 – 15:50

Flash talks - Session 2

Chair: Simone Fulda (Frankfurt, Germany)
Seung-Won Choi (poster Noh), Adrien Nougarede, Michaela Ohmer, Jinho Seo, Raquel Salvador-Gallego, Doaa Tawfik, Selma Tuzlak, Juan Garcia Valero, Sarka Vosahlikova, Tianqi Xu

15:50 - 16:20

Coffee break

16:20 – 18:15

Session 3b: Stress and cell death

Chair: Francois Vallette (Nantes, France)

Boris TURK (Ljubljana, Slovenia)
Cysteine cathepsins: cell killing or tumor promoting in cancer?
Guido KROEMER (Paris, France)
Immunogenic cell stress and death in anticancer immunosurveillance
Raffaella Iurlaro (Barcelona, Spain)
Glucose deprivation induces ATF4-mediated apoptosis through TRAIL receptors DR4/TRAIL-R1 and DR5/TRAIL-R2
CDD Jurg Tshopp award presentation: Peter Vandenabeele (Ghent, Belgium)
Regulation of the core necroptosis pathway by nuclear events

18:15- 20:15

Poster session 2

(+ refreshments)



Friday September 30, 2016

09:00 – 12:45

Session 4: Inflammation and cell death

Chairs: Gerry Melino (Rome/Leicester, UK) - Thomas Brunner (Konstanz, Germany)
John BERTIN (Pennsylvania, USA)
RIPK1 therapeutics—From concept to patients with immune-mediated inflammatory diseases
Domagoj VUCIC (San Francisco, USA)
Regulation of inflammation and cell death by RIP kinases
Ulrich Maurer (Freiburg, Germany)
SPATA2 promotes CYLD activity and regulates TNF-induced NF-kB signaling and cell death

10:45 - 11:15

Coffee break

Henning  WALCZAK (London, UK)
Cell death in cancer, inflammation and immunity
Seamus MARTIN (Dublin, Ireland)
TRAIL-induced Inflammatory signaling: a DISC with a Twist
Lynn Wong (Zurich, Switzerland)
RIPK3 promotes vascular permeability via VEGF/p38 axis to allow tumor cell extravasation independent of its kinase activity

12:30 – 14:00

Lunch on site

14:00 – 15:30

Session 5: Death Receptors and caspase activating complexes

Chair : Núria Sánchez-Coll, Barcelona, Spain
Marion MACFARLANE (Leicester, UK)
A Unified Model for c-FLIP regulation of Caspase-8 and control of life/death decisions
Andreas VILLUNGER (Innsbruck, Austria)
Controlling cell death in and out of mitosis
Eli Arama (Rehovot, Israel)
Caretakers of tissue integrity: A non-apoptotic role of caspases in preventing unwanted cell migration and invasion
Dagmar Kulms (Dresden, Germany)
Caspase-8 promotes uncontrolled progression of cancer cells

15:30 - 16:00

Coffee break

16:00 – 18:00

Session 6: Death modulators in the clinic

Chair: Joan Gil, Barcelona, Spain
Eric Eldering (Amsterdam, Netherlands)
BH3 mimetics as combination drugs and as profiling tools in CLL
Joan Montero (Boston, USA)
Using Dynamic BH3 Profiling to employ BH3 mimetics for improving cancer treatment
Markus Rehm (Stuttgart, Germany)
A stepwise integrated approach to personalized risk predictions in stage III colorectal cancer building on tumor apoptosis competency
Ana Janic (Melbourne, Australia)
shRNA screens indicate that DNA repair is the process critical for p53-mediated tumour suppression
ECDO Honorary Lecture: Andreas STRASSER (Melbourne, Australia)
Which pro-survival BCL-2 family member should be targeted for the treatment of which cancer?
Poster and flash talk awards


Conference dinner



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